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Anti-obesity Supplement

We are all well aware that obesity is an epidemic problem in the world. It is also one of the leading causes of death. It leads to so many chronic diseases. There seems to be a new supplement they could help to change all that!

Ketones are a big topic of conversation in the health world at the moment. There is a very good reason why. Ketones are our ultimate energy source. We only have two fuel sources in our bodies – glucose and ketones. The problem is due to most peoples diets they never experience being run on ketones. They are just glucose burning all day long. People wonder why they are burnt out, tired, don’t sleep well, moody, lack of energy, struggle to lose weight etc.

This is a fascinating research article on the power of ketones. To give you some background an a few things you may be unaware of. The study was with ketones esters which is a different form than ketones salts which is what most ketone supplements are made from.  There are different types of fat in our body. We want more brown fat. One of the biggest takeaways from this article is the increase mitochondrial biogenesis. Mitochondria are like the fuel cells of our body. They are so important to keep functioning well. It is a massive statement they make saying that ketones are a potential anti-obesity supplement.


Mitochondrial biogenesis and increased uncoupling protein 1 in brown adipose tissue of mice fed a ketone ester diet.

FASEB J 2012 Jun 23;26(6):2351-62. Epub 2012 Feb 23. Shireesh Srivastava, Yoshihiro Kashiwaya, M Todd King, Ulrich Baxa, Joseph Tam, Gang Niu, Xiaoyuan Chen, Kieran Clarke, Richard L Veech

We measured the effects of a diet in which D-β-hydroxybutyrate-(R)-1,3 butanediol monoester ketone ester replaced equicaloric amounts of carbohydrate on 8-wk-old male mice. Diets contained equal amounts of fat, protein, and micronutrients. The Ketone ester group was fed ad libitum, whereas the control mice were pair-fed to the Ketone ester group. Blood d-β-hydroxybutyrate levels in the Ketone ester group were 3-5 times those reported with high-fat ketogenic diets. Voluntary food intake was reduced dose dependently with the Ketone ester diet. Feeding the Ketone ester diet for up to 1 mo increased the number of mitochondria and doubled the electron transport chain proteins, uncoupling protein 1, and mitochondrial biogenesis-regulating proteins in the interscapular brown adipose tissue (IBAT). [(18)F]-Fluorodeoxyglucose uptake in IBAT of the Ketone ester group was twice that in IBAT of the Control group. The Ketone ester group exhibited 14% greater resting energy expenditure. The quantitative insulin-sensitivity check index was 73% higher in the KE group.

These results identify Ketone ester as a potential antiobesity supplement.

Feeding the ketone ester diet ad lib decreased voluntary food intake 2-fold.  1.5-fold increase in brain uncoupling proteins 4 and 5. Feeding ketone ester or palm oil supplemented diets decreased brain L-glutamate by 15-20% and GABA by about 34% supporting the view that fatty acids as well as ketone bodies can be metabolized by the brain.

If you are interested in knowing more about ketones, ketogenic diet and the ketone supplement reach out to Dr. Andrew Timbs at Purity Chiropractic.

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